This keynote explores the cutting-edge advancements in AI-driven perception systems for drones operating in GPS-denied environments. It focuses on how artificial intelligence can enable autonomous drones to navigate, detect, and respond to real-time challenges without reliance on GPS, significantly enhancing their effectiveness in defense and surveillance missions. Attendees will learn about the latest innovations in sensor fusion, computer vision, and machine learning that are shaping the future of drone operations in complex, contested environments.